circRNA basic information
circBase ID: hsa_circ_0005228
Name: hsa_circ_PHC3
Synonym: circ-PHC3
Host Gene: hsa-miR-497-5p
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human ovarian epithelial cell line (IOSE80), OC cell lines (SKOV3, OV90)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SOX9
Associated microRNA: hsa-miR-497-5p
Biological function: Downregulation of circ-PHC3 led to suppression of metastasis and proliferation
Molecular mechanism: circ-PHC3/hsa-miR-497-5p/SOX9 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Taken together, our findings suggest that circ-PHC3 enhances OC progression through functioning as an miR-497-5p sponge to promote SOX9 expression, supporting its potential as a promising candidate target for OC therapy.
Other information
Title:

Expression of circ-PHC3 enhances ovarian cancer progression via regulation of the miR-497-5p/SOX9 pathway

Journal: J Ovarian Res
Published: 2023/7/20
PubMed ID: 37468993