circRNA basic information
circBase ID: hsa_circ_0001346
Name: hsa_circ_RNF13
Synonym: circRNF13
Host Gene: -
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: CC cell lines (SiHa, C-4I, HeLa, C-33A), normal cervical epithelial cell line (End1/E6E7)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: METTL3, YTHDF2, CXCL1
Associated microRNA: -
Biological function: Experiments conducted both in vitro and in vivo confirmed that the knockdown of circRNF13 potentiated the radiosensitivity of CC cells
Molecular mechanism: METTL3/YTHDF2/circRNF13/CXCL1 axis
Survival: -
Supported No.:
 1
Description:

This study identified circRNF13 as a novel m6A-modified circRNA and validated the METTL3/YTHDF2/circRNF13/CXCL1 axis as a potential target for CC radiotherapy.
Other information
Title:

circRNF13, a novel N6-methyladenosine-modified circular RNA, enhances radioresistance in cervical cancer by increasing CXCL1 mRNA stability

Journal: Cell Death Discov
Published: 2023/7/20
PubMed ID: 37468464