circRNA basic information
circBase ID: hsa_circ_0000285
Name: hsa_circ_HIPK3
Synonym: circ_0000285
Host Gene: hsa-miR-582-3p
 
 
 
Disease basic information
DO ID:
 769
DO name: neuroblastoma
Disease details: neuroblastoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: NB cell lines (SK-N-BE, SK-N-SH, SK-N-AS, IMR-32), non-cancerous (HEK293)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-582-3p
Biological function: In vivo animal models were prepared for the functional verification of circ_0000285 on tumor growth. In vivo and in vitro experiments indicated that the absence of circ_0000285 repressed NB cell proliferation and migration, provoked apoptosis, and impaired the activity of Wnt/beta-catenin signaling
Molecular mechanism: Wnt/beta-catenin
Survival: -
Supported No.:
 1
Description:

Circ_0000285 functions as an miR-582-3p sponge to strengthen Wnt/beta-catenin signaling activity, thus exacerbating NB development.
Other information
Title:

hsa_circ_0000285 sponging miR-582-3p promotes neuroblastoma progression by regulating the Wnt/beta-catenin signaling pathway

Journal: Open Med (Wars)
Published: 2023/7/14
PubMed ID: 37465351