circRNA basic information
circBase ID: -
Name: hsa_circ_THBS1
Synonym: -
Host Gene: hsa-miR-543
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human cervical epithelial cell line (Ect1/E6E7), cervical cancer cell lines (C-33A, SiHa, CaSki, HeLa)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGB2
Associated microRNA: hsa-miR-543
Biological function: Silencing of circRNA THBS1 remarkably suppressed HeLa cells viability, accelerated cells apoptosis, and inhibited the EMT of HeLa cells
Molecular mechanism: circ_THBS1/hsa-miR-543/HMGB2 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

In conclusion, circRNA THBS1 silencing inhibited the malignant biological behaviors of cervical cancer cells via the regulation of miR-543/HMGB2 axis.
Other information
Title:

circRNA THBS1 silencing inhibits the malignant biological behavior of cervical cancer cells via the regulation of miR-543/HMGB2 axis

Journal: Open Med (Wars)
Published: 2023/7/14
PubMed ID: 37465349