circRNA basic information
circBase ID: hsa_circ_0072088
Name: hsa_circ_ZFR
Synonym: CircZFR
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3910
DO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human LUAD cells (A549, HCC827, H1975, PC9)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HNRNPLL, MYO1B, OXPHOS
Associated microRNA: -
Biological function: CircZFR is strongly associated with higher T stage and poor prognosis in patients with LUAD
Molecular mechanism: CircZFR/HNRNPLL/MYO1B axis, AKT-mTOR pathway
Survival: poor
Supported No.:
 2
Description:

Our study provides new insights into the role of circRNAs in anticancer metabolic therapies and expands our understanding of alternative splicing.
Other information
Title:

Energy stress-induced circZFR enhances oxidative phosphorylation in lung adenocarcinoma via regulating alternative splicing

Journal: J Exp Clin Cancer Res
Published: 2023/7/17
PubMed ID: 37461053