circRNA basic information
circBase ID: hsa_circ_0000376
Name: hsa_circ_PRH1-PRR4
Synonym: circ_0000376
Host Gene: hsa-miR-1298-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human bronchial epithelial (HBE), A549, H1299 cells, Paclitaxel (PTX) resistant cells (A549/PTX, H1299/PTX cells)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: KPNA4
Associated microRNA: hsa-miR-1298-5p
Biological function: Circ_0000376 depletion promoted PTX sensitivity and apoptosis, while suppressing the proliferation, migration, and invasion of PTX-resistant NSCLC cells.
Molecular mechanism: Circ_0000376/hsa-miR-1298-5p/KPNA4 axis, miRNA sponge
Survival: -
Supported No.:
 4
Description:

Circ_0000376 facilitated PTX resistance and tumorigenesis of NSCLC by miR-1298-5p/KPNA4 axis, suggesting an underlying therapeutic strategy for NSCLC.
Other information
Title:

Circular RNA circ_0000376 promotes paclitaxel resistance and tumorigenesis of non-small cell lung cancer via positively modulating KPNA4 by sponging miR-1298-5p

Journal: Thorac Cancer
Published: 2023/7/16
PubMed ID: 37455373