circRNA basic information
circBase ID: -
Name: hsa_circ_RPS19
Synonym: circRPS19
Host Gene: hsa-miR-125a-5p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human GC cell lines (AGS, HGC-27, NCI-N87, SNU-1)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: USP7
Associated microRNA: hsa-miR-125a-5p
Biological function: Loss_of function assays revealed that silencing of circRPS19 suppressed proliferation and aerobic glycolysis but increased apoptosis of GC cells.
Molecular mechanism: circRPS19/USP7/miR_125a_5p axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Taken together, circRPS19 induced aerobic glycolysis of GC cells by stabilizing HK2 protein via the miR_125a_5p/USP7 axis and thus promoting the progression of GC.
Other information
Title:

circRPS19 affects HK2_mediated aerobic glycolysis and cell viability via the miR_125a_5p/USP7 pathway in gastric cancer

Journal: Int J Oncol
Published: 2023/7/10
PubMed ID: 37449524