circRNA basic information
circBase ID: hsa_circ_0001589
Name: hsa_circ_HIST1H1D
Synonym: circ_0001589
Host Gene: hsa-miR-1248
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human immortalized cervical epithelial cell line (HcerEpic)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGB1
Associated microRNA: hsa-miR-1248
Biological function: Circ_0001589 increased the number of lung metastases and recovered xenograft growth from cisplatin treatment in vivo
Molecular mechanism: Circ_0001589/hsa-miR-1248/HMGB1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

In summary, our findings suggest the upregulation of circ_0001589 promoted EMT-mediated cell migration and invasion, and enhanced cisplatin resistance via regulating miR-1248/HMGB1 axis in cervical cancer.
Other information
Title:

Circ_0001589/miR-1248/HMGB1 axis enhances EMT-mediated metastasis and cisplatin resistance in cervical cancer

Journal: Mol Carcinog
Published: 2023/7/11
PubMed ID: 37431919