circRNA basic information
circBase ID: hsa_circ_0050102
Name: hsa_circ_PGPEP1
Synonym: circPGPEP1
Host Gene: hsa-miR-515-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NFAT5
Associated microRNA: hsa-miR-515-5p
Biological function: circPGPEP1 silencing not only effectively inhibited CRC cell proliferation, migration, EMT, and immune escape and promoted apoptosis in vitro, but also inhibited CRC tumor growth and immune escape in vivo
Molecular mechanism: circPGPEP1/hsa-miR-515-5p/NFAT5 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Collectively, circPGPEP1 exerts an oncogene role in CRC by regulating the miR-515-5p/NFAT5 axis.
Other information
Title:

Circular RNA PGPEP1 induces colorectal cancer malignancy and immune escape

Journal: Cell Cycle
Published: 2023/7/9
PubMed ID: 37424115