circRNA basic information
circBase ID: hsa_circ_0001387
Name: hsa_circ_WHSC1
Synonym: CircWHSC1
Host Gene: hsa-miR-590-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human NSCLC cell lines (A549, H460, H1730, PC9, H1229), immortalized human bronchial epithelial cells (HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SOX5
Associated microRNA: hsa-miR-590-5p
Biological function: The inhibition of circWHSC1 suppressed the malignant properties of NSCLC cells, as evidenced by the reduction of proliferation, migration and invasion.
Molecular mechanism: CircWHSC1/hsa-miR-590-5p/SOX5 axis, miRNA sponge
Survival: -
Supported No.:
 3
Description:

CircWHSC1 may contribute to the oncogenicity of NSCLC via the regulation of miR-590-5p/SOX5 axis, which might be a novel therapeutic target in NSCLC.
Other information
Title:

CircWHSC1 serves as a prognostic biomarker and promotes malignant progression of non-small-cell lung cancer via miR-590-5p/SOX5 axis

Journal: Environ Toxicol
Published: 2023/7/7
PubMed ID: 37417879