circRNA basic information
circBase ID: hsa_circ_0001944
Name: hsa_circ_FIRRE
Synonym: circ-FIRRE
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human ESCC cell lines (KYSE-30, KYSE-150, KYSE-410, KYSE-510, Eca-109), a human esophageal epithelial cell line (HEEC)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: HNRNPC, GLI2, MYC, CCNE1, CCNE2
Associated microRNA: -
Biological function: Furthermore, we observed marked circ-FIRRE overexpression in ESCC patients with high TNM stage and poor overall survival
Molecular mechanism: circ-FIRRE/HNRNPC/GLI2 axis
Survival: poor
Supported No.:
 1
Description:

In summary, our results indicate that circ-FIRRE could serve as a valuable biomarker and potential therapeutic target for ESCC and highlight a novel mechanism of the circ-FIRRE/HNRNPC complex in ESCC progression regulation.
Other information
Title:

Circular RNA circ-FIRRE interacts with HNRNPC to promote esophageal squamous cell carcinoma progression by stabilizing GLI2 mRNA

Journal: Cancer Sci
Published: 2023/7/7
PubMed ID: 37417427