circRNA basic information
circBase ID: hsa_circ_0009362
Name: hsa_circ_GNB1
Synonym: circGNB1
Host Gene: hsa-miR-515-5p, hsa-miR-582-3p
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: brain glioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human glioma cell lines (U87, U251)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: XPR1
Associated microRNA: hsa-miR-515-5p, hsa-miR-582-3p
Biological function: Functional assays demonstrated that circGNB1 overexpression promoted glioma stem cells (GSCs) viability proliferation, invasion, and neurosphere formation.
Molecular mechanism: circGNB1/hsa-miR-515-5p/hsa-miR-582-3p/XPR1 axis, miRNA sponge
Survival: poor
Supported No.:
 1
Description:

Our study reveals that circGNB1 plays a crucial role in promoting tumorigenesis and malignant progression in glioma, which provides a promising cancer biomarker.
Other information
Title:

CircGNB1 facilitates the malignant phenotype of GSCs by regulating miR-515-5p/miR-582-3p-XPR1 axis

Journal: Cancer Cell Int
Published: 2023/7/5
PubMed ID: 37407973