circRNA basic information
circBase ID: hsa_circ_0019079
Name: hsa_circ_KIF20B
Synonym: circKIF20B
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: gefitinib-resistant NSCLC cell lines (PC9GR, HCC827GR)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: MEF2A
Associated microRNA: -
Biological function: Decreasing circKIF20B was found to promote gefitinib resistance by accelerating the cell cycle, inhibiting apoptosis, and enhancing mitochondrial oxidative phosphorylation (OXPHOS), whereas increasing circKIF20B was found to restore gefitinib sensitivity
Molecular mechanism: circKIF20B/hsa-miR-615-3p/MEF2A axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

This study revealed a novel mechanism of circKIF20B/miR-615-3p/MEF2A signaling axis involving progression of gefitinib resistance in NSCLC.
Other information
Title:

Exosome-derived circKIF20B suppresses gefitinib resistance and cell proliferation in non-small cell lung cancer.

Journal: Cancer Cell Int
Published: 2023/7/3
PubMed ID: 37394466