circRNA basic information
circBase ID: -
Name: hsa_circ_TBX5
Synonym: circTBX5
Host Gene: hsa-miR-558
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: IL-1beta-treated C28/I2 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MyD88
Associated microRNA: hsa-miR-558
Biological function: IL-1beta induced C28/I2 cell injury by impairing cell viability and proliferation and promoting cell apoptosis, ECM degradation and inflammatory response, while circTBX5 knockdown alleviated IL-1beta induced injury.
Molecular mechanism: CircTBX5 bound to miR-558 to regulate IL-1beta induced cell injury. In addition, MyD88 was a target of miR-558, and circTBX5 targeted miR-558 to positively regulate MyD88 expression.
Survival: -
Supported No.:
 1
Description:

CircTBX5 knockdown modulated the miR-558/MyD88 axis to alleviate IL-1beta induced chondrocyte apoptosis, ECM degradation and inflammation via inactivating the NF-§ÜB signaling pathway.
Other information
Title:

CircTBX5 knockdown modulates the miR-558/MyD88 axis to alleviate IL-1beta-induced inflammation, apoptosis and extracellular matrix degradation in chondrocytes via inactivating the NF-kappaB signaling.

Journal: J Orthop Surg Res
Published: 2023/7/2
PubMed ID: 37393232