circRNA basic information
circBase ID: hsa_circ_0087856
Name: hsa_circ_RAD23B
Synonym: -
Host Gene: hsa-miR-1184
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: BC cell lines (T24, EJ, 5637) , human bladder epithelial immortalized cell line (SVHUC-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CITED2
Associated microRNA: hsa-miR-1184
Biological function: Hsa_circ_0087856 silencing suppressed BC tumor growth, and contributed to the inhibition of cisplatin to tumor growth. In cellular experiments, hsa_circ_0087856 increasing promoted BC cells proliferation, migration and invasion, and inhibited the cells apoptosis. Hsa_circ_0087856 increasing partly reversed the inhibition of cisplatin to BC cell proliferation and the promotion to cell apoptosis. Oppositely, hsa_circ_0087856 silencing could increase the sensitivity of BC cells to cisplatin.
Molecular mechanism: hsa_circ_0087856/hsa-miR-1184/CITED axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Overall, our results revealed the role of hsa_circ_0087856 that downregulation its expression could enhance the BC cells sensitivity to cisplatin by facilitating CITED expression via sponging miR-1184.
Other information
Title:

Downregulation of circular RNA hsa_circ_0087856 sensitizes bladder cancer cells to cisplatin through targeting miR-1184/CITED2 signaling.

Journal: Environ Mol Mutagen
Published: 2023/7/1
PubMed ID: 37392146