circRNA basic information
circBase ID: hsa_circ_0042174
Name: hsa_circ_NCOR1
Synonym: circNCOR1
Host Gene: hsa-miR-638
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human TNBC cell lines (MDA-MB-231, BT549)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CDK2
Associated microRNA: hsa-miR-638
Biological function: overexpression of circNCOR1 partially reversed radiation-induced loosening of tumor structures and enhanced tumor cell proliferation.
Molecular mechanism: circNCOR1/hsa-miR-638/CDK2 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Our results demonstrated that circNCOR1 bounds to hsa-miR-638 and targets CDK2, thereby regulating the radiosensitivity of TNBC.
Other information
Title:

CircNCOR1 regulates breast cancer radiotherapy efficacy by regulating CDK2 via hsa-miR-638 binding.

Journal: Cell Signal
Published: 2023/7/1
PubMed ID: 37391048