circRNA basic information
circBase ID: -
Name: hsa_circ_CCDC66
Synonym: circRNA_CCDC66
Host Gene: hsa-miR-342-3p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human monocytes THP-1, human embryonic kidney (HEK)-293 T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MTDH
Associated microRNA: hsa-miR-342-3p
Biological function: Suppression of circ_CCDC66 in the M2-EVs or specific knockdown of MTDH in CRC significantly blocked the growth and mobility of CRC cells
Molecular mechanism: circ_CCDC66/hsa-miR-342-3p/MTDH axis, miRNA sponge
Survival: -
Supported No.:
 4
Description:

In summary, this study reveals that the M2-EVs augment immune evasion and development of CRC by delivering circ_CCDC66 and restoring the MTDH level.
Other information
Title:

M2 macrophage-derived extracellular vesicles augment immune evasion and development of colorectal cancer via a circRNA_CCDC66/microRNA-342-3p/metadherin axis.

Journal: Cytotechnology
Published: 2023/6/30
PubMed ID: 37389129