circRNA basic information
circBase ID: hsa_circ_0001947
Name: hsa_circ_AFF2
Synonym: circAFF2
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: RKO, SW480, HT_29, LoVo, HCT_116, SW620, NCM460
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: ALKBH5, YTHDF2
Associated microRNA: -
Biological function: circAFF2 can enhance the radiosensitivity of CRC cells both in vitro and in vivo
Molecular mechanism: ALKBH5/YTHDF2/circAFF2/Cullin-NEDD8 axis
Survival: better
Supported No.:
 1
Description:

We identified and characterised circAFF2 as a novel m6A-modified circRNA and validated the ALKBH5/YTHDF2/circAFF2/Cullin-NEDD8 axis as a potential radiotherapy target for CRC.
Other information
Title:

ALKBH5/YTHDF2-mediated m6A modification of circAFF2 enhances radiosensitivity of colorectal cancer by inhibiting Cullin neddylation.

Journal: Clin Transl Med
Published: 2023/6/29
PubMed ID: 37381158