circRNA basic information
circBase ID: hsa_circ_0086414
Name: hsa_circ_BNC2
Synonym: circ-BNC2
Host Gene: hsa-miR-142-3p
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: GNAS
Associated microRNA: hsa-miR-142-3p
Biological function: Circ-BNC2 overexpression repressed the proliferation, migration and invasion of OSCC cells but induced cell apoptosis and oxidative stress. Additionally, circ-BNC2 overexpression inhibited tumor growth in vivo.
Molecular mechanism: Circ-BNC2/hsa-miR-142-3p/GNAS axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

Circ-BNC2 suppressed OSCC malignant progression by upregulating GNAS expression in a miR-142-3p-dependent manner, which suggested that circ-BNC2 might be a novel target for OSCC therapy.
Other information
Title:

The role and mechanism of circ-BNC2 on the malignant progression of oral squamous cell carcinoma.

Journal: Head Neck
Published: 2023/6/28
PubMed ID: 37377048