circRNA basic information
circBase ID: hsa_circ_0066568
Name: hsa_circ_ROBO1
Synonym: circROBO1
Host Gene: hsa-miR-130a-5p
 
 
 
Disease basic information
DO ID:
 3571
DO name: liver cancer
Disease details: liver cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human liver cancer cells Huh-7 (CL-0120), SNU-182 (CL-0610)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ROBO1
Associated microRNA: hsa-miR-130a-5p
Biological function: overexpression of circROBO1 partly recovered the effect of matrine on liver cancer cell viability, proliferation, apoptosis
Molecular mechanism: circROBO1/hsa-miR-130a-5p/ROBO1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Matrine impeded liver cancer development by mediating the circROBO1/miR-130a-5p/ROBO1 axis, which provided a theoretical basis for the application of matrine as an effective anticancer drug for liver cancer.
Other information
Title:

Matrine suppresses liver cancer progression and the Warburg effect by regulating the circROBO1/miR-130a-5p/ROBO1 axis.

Journal: J Biochem Mol Toxicol
Published: 2023/6/28
PubMed ID: 37376914