circRNA basic information
circBase ID: hsa_circ_0002359
Name: hsa_circ_UHRF2
Synonym: circUHRF2
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human colon epithelial cells line (FHC), CRC cell lines (LoVo, SW480, SW620, HCT116, HCT8)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: DDX27, IGF2BP1
Associated microRNA: -
Biological function: circUHRF2 or METTL3 silencing exerted a suppressive effect on CRC growth and liver metastasis via repressing DDX27 protein expression
Molecular mechanism: circUHRF2/DDX27/IGF2BP1 axis
Survival: -
Supported No.:
 1
Description:

Taken together, METTL3-mediated m6A modification upregulated circUHRF2 and subsequently inhibited loss of DDX27 protein via recruitment of IGF2BP1, which conferred CRC stemness and metastasis.
Other information
Title:

METTL3-Modulated circUHRF2 Promotes Colorectal Cancer Stemness and Metastasis through Increasing DDX27 mRNA Stability by Recruiting IGF2BP1.

Journal: Cancers (Basel)
Published: 2023/6/28
PubMed ID: 37370759