circRNA basic information
circBase ID: hsa_circ_0009096
Name: hsa_circ_UTRN
Synonym: circUTRN24
Host Gene: hsa-miR-483-3p
 
 
 
Disease basic information
DO ID:
 409
DO name: liver disease
Disease details: liver fibrosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human HSC line (LX-2), 293 T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IGF-1
Associated microRNA: hsa-miR-483-3p
Biological function: si-circUTRN24 significantly decreased circUTRN24 expression and inhibited HSC activation and autophagy, which was reversed by Rapamycin
Molecular mechanism: circUTRN24/hsa-miR-483-3p/IGF-1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

These findings imply that circUTRN24/miR-483-3p/IGF-1 axis mediated LX-2 cell fibrosis by regulating autophagy.
Other information
Title:

CircUTRN24/miR-483-3p/IGF-1 Regulates Autophagy Mediated Liver Fibrosis in Biliary Atresia.

Journal: Mol Biotechnol
Published: 2023/6/28
PubMed ID: 37369954