circRNA basic information
circBase ID: hsa_circ_0060665
Name: hsa_circ_ARFGEF2
Synonym: circARFGEF2
Host Gene: hsa-miR-1205
 
 
 
Disease basic information
DO ID:
 3498
DO name: pancreatic ductal adenocarcinoma
Disease details: pancreatic ductal adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human lymphatic endothelial cells (HLECs)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: JAK2, STAT3, KRASG12D
Associated microRNA: hsa-miR-1205
Biological function: CircARFGEF2 overexpression significantly facilitated KRASG12D PDAC LN metastasis in vitro and in vivo
Molecular mechanism: circARFGEF2/KrasG12D/+Trp53R172H/+Pdx-1-Cre axis
Survival: -
Supported No.:
 1
Description:

CircARFGEF2 sponged miR-1205 and promoted the activation of JAK2, which phosphorylated STAT3 to trigger KRASG12D PDAC lymphangiogenesis and LN metastasis.
Other information
Title:

Mutant KRAS mediates circARFGEF2 biogenesis to promote lymphatic metastasis of pancreatic ductal adenocarcinoma.

Journal: Cancer Res
Published: 2023/6/26
PubMed ID: 37363990