circRNA basic information
circBase ID: hsa_circ_0003220
Name: hsa_circ_TMCO7
Synonym: circ_0003220
Host Gene: hsa-miR-489-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: 293T, H460, A549, primary human bronchial epithelial (HBE) cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IGF1
Associated microRNA: hsa-miR-489-3p
Biological function: hsa_circ_0003220 knockdown reduced chemoresistance
Molecular mechanism: circ_0003220/hsa-miR-489-3p/IGF1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

By controlling the miR-489-3p/IGF1 axis, hsa_circ_0003220 knockdown helped NSCLC overcome chemoresistance, suggesting a potential circRNA-targeted therapy for the disease.
Other information
Title:

Hsa_circ_0003220 Drives Chemoresistance of Human NSCLC Cells by Modulating miR-489-3p/IGF1.

Journal: Int J Genomics
Published: 2023/6/26
PubMed ID: 37361693