circRNA basic information
circBase ID: hsa_circ_0005085
Name: hsa_circ_ASAP2
Synonym: circ_0005085
Host Gene: hsa-miR-186-5p
 
 
 
Disease basic information
DO ID:
 1749
DO name: squamous cell carcinoma
Disease details: squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: CSCC lines (HSC-1, A431), human benign epidermal keratinocyte cell line (HaCaT), 293T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: LAMC1
Associated microRNA: hsa-miR-186-5p
Biological function: Overexpression of hsa_circ_0005085 inhibited cell proliferation, migration, invasion, epithelial-mesenchymal transition (EMT), and promoted cell apoptosis in CSCC
Molecular mechanism: circ_0005085/hsa-miR-186-5p/LAMC1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

In our study, hsa_circ_0005085 might inhibit CSCC development by targeting the miR-186-5p/LAMC1 axis, which might provide a promising therapeutic target for CSCC.
Other information
Title:

Hsa_circ_0005085 may suppress cutaneous squamous cell carcinoma growth and metastasis through targeting the miR-186-5p/LAMC1 axis.

Journal: Skin Res Technol
Published: 2023/6/26
PubMed ID: 37357644