circRNA basic information
circBase ID: hsa_circ_0000033
Name: hsa_circ_CEP85
Synonym: circ_0000033
Host Gene: hsa-miR-378a-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal mammary epithelial cell line (MCF10A), human BC cell lines (MDA-MB-231, BT549, MCF7), human umbilical vein endothelial cells (HUVECs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NUAK2
Associated microRNA: hsa-miR-378a-3p
Biological function: knockdown of circ_0000033 suppressed BC cell proliferation, migration, invasion, angiogenesis, and induced apoptosis and cell cycle arrest in vitro. An in vivo experiment was conducted using a murine xenograft model and showed circ_0000033 silencing also impeded the growth of BC in nude mice
Molecular mechanism: circ_0000033/hsa-miR-378a-3p/NUAK2 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Overall, circ_0000033 up-regulates NUAK2 through sequestration miR-378a-3p, which promoted breast tumorigenesis, suggesting circ_0000033 is a promising therapeutic target for BC treatment.
Other information
Title:

Circ_0000033 up-regulates NUAK2 by sequestering miR-378a-3p to promote breast tumorigenesis.

Journal: Environ Mol Mutagen
Published: 2023/6/26
PubMed ID: 37357410