circRNA basic information
circBase ID: hsa_circ_0100213
Name: hsa_circ_USPL1
Synonym: circUSPL1
Host Gene: hsa-miR-1296-5p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal breast epithelial cell line (MCF-10A), BC cell lines (MDA-MB-231, MDA-MB-468, SKBR3, BT549, MCF-7), HEK293T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MTA1
Associated microRNA: hsa-miR-1296-5p
Biological function: CircUSPL1 deficiency significantly inhibited BC cell proliferation, migration, invasion, glycolysis, and promoted cell apoptosis
Molecular mechanism: circUSPL1/hsa-miR-1296-5p/MTA1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

CircUSPL1 deficiency repressed BC cell malignant phenotypes through reducing MTA1 via targeting miR-1296-5p, which might provide a theoretical basis for BC treatment.
Other information
Title:

Silencing of circUSPL1 represses breast cancer progression by targeting miR-1296-5p/MTA1 axis.

Journal: Thorac Cancer
Published: 2023/6/23
PubMed ID: 37349877