circRNA basic information
circBase ID: hsa_circ_0020123
Name: hsa_circ_PDZD8
Synonym: circ-PDZD8
Host Gene: hsa-miR-330-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, PDX
Sample type details: NSCLC cells (A549, H520), noncancerous BEAS-2B cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: LARP1
Associated microRNA: hsa-miR-330-5p
Biological function: Circ-PDZD8 knockdown inhibited cell growth, migratory capacity, invasiveness and glutamine metabolism but enhanced cell apoptosis in NSCLC cells
Molecular mechanism: Circ-PDZD8/hsa-miR-330-5p/LARP1 axis, miRNA sponge
Survival: -
Supported No.:
 9
Description:

Circ-PDZD8 promotes NSCLC cell growth and glutamine metabolism by increasing LARP1 via competitively targeting miR-330-5p.
Other information
Title:

Circ-PDZD8 promotes cell growth and glutamine metabolism in non-small cell lung cancer by enriching LARP1 via sequestering miR-330-5p.

Journal: Thorac Cancer
Published: 2023/6/23
PubMed ID: 37349870