circRNA basic information
circBase ID: hsa_circ_0016142
Name: hsa_circ_PIK3C2B
Synonym: circ_0016142
Host Gene: hsa-miR-188-3p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: THLE3, Hep3B, HA22T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: GPX4
Associated microRNA: hsa-miR-188-3p
Biological function: Circ_0016142 silencing reduced cell proliferation and GSH levels
Molecular mechanism: circ_0016142/hsa-miR-188-3p/GPX4 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

In conclusion, circ_0016142 silencing suppressed HCC cell proliferation by inducing ferroptosis via the miR-188-3p/GPX4 axis.
Other information
Title:

Circular RNA 0016142 Knockdown Induces Ferroptosis in Hepatocellular Carcinoma Cells via Modulation of the MicroRNA-188-3p/Glutathione Peroxidase 4 Axis.

Journal: Biochem Genet
Published: 2023/6/22
PubMed ID: 37344692