circRNA basic information
circBase ID: hsa_circ_0010024
Name: hsa_circ_DHRS3
Synonym: circDHRS3
Host Gene: hsa-miR-193a-3p
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Chondrocytes (C28/I2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MECP2
Associated microRNA: hsa-miR-193a-3p
Biological function: CircDHRS3 silencing weakened IL-1beta-induced chondrocyte cartilage extracellular matrix (ECM) degradation, apoptosis, and inflammatory response.
Molecular mechanism: CircDHRS3 adsorbed miR-193a-3p to modulate MECP2 expression.
Survival: -
Supported No.:
 2
Description:

CircDHRS3 silencing reduced MECP2 expression via sponging miR-193a-3p, thereby weakening IL-1beta-induced chondrocyte ECM degradation, apoptosis, and inflammatory response.
Other information
Title:

Circular RNA CircDHRS3 Aggravates IL-1beta-induced ECM Degradation, Apoptosis, and Inflammatory Response via Mediating MECP2 Expression.

Journal: Inflammation
Published: 2023/6/21
PubMed ID: 37340152