circRNA basic information
circBase ID: hsa_circ_0058063
Name: hsa_circ_ATIC
Synonym: circ_0058063
Host Gene: hsa-miR-557
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: a normal breast cell line (MCF-10A), BC cell lines (MDA-MB-231, MDA-MB-468)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: DLGAP5
Associated microRNA: hsa-miR-557
Biological function: circ_0058063 knockdown inhibited proliferation and migration but promoted apoptosis in MCF-7 and MDA-MB-231 cells in vitro. In vivo studies further validated that the knockdown of circ_0058063 repressed tumor growth
Molecular mechanism: circ_0058063/hsa-miR-557/DLGAP5 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

These findings suggest that the circ_0058063/miR-557/DLGAP5 axis is an important regulator of oncogenic function and may be a promising therapeutic target for BC.
Other information
Title:

circ_0058063 promotes breast cancer progression by upregulating DLGAP5 via sponging miR-557.

Journal: Cancer Biomark
Published: 2023/6/19
PubMed ID: 37334578