circRNA basic information
circBase ID: hsa_circ_0000043
Name: hsa_circ_PUM1
Synonym: -
Host Gene: hsa-miR-4492
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human bronchial epithelial cells (16HBE), human lung cancer cell lines (A549, H1299, H446, 95D)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: BDNF, STAT3
Associated microRNA: hsa-miR-4492
Biological function: hsa_circ_0000043 inhibition suppressed 16HBE-T cell proliferation, migration, and invasion. Furthermore, hsa_circ_0000043 inhibition suppressed tumor growth in a mouse xenograft model
Molecular mechanism: hsa_circ_0000043/hsa-miR-4492/BDNF/STAT3 axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

Thus, hsa_circ_0000043 was shown to contribute to the proliferation, malignant transformation ability, migration, and invasion of 16HBE-T cells via miR-4492 sponging and BDNF and STAT3 involvement.
Other information
Title:

CircRNA hsa_circ_0000043 acts as a miR-4492 sponge to promote lung cancer progression via BDNF and STAT3 expression regulation in anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide-transformed 16HBE Cells.

Journal: Toxicol Sci
Published: 2023/6/16
PubMed ID: 37326964