circRNA basic information
circBase ID: hsa_circ_0012634
Name: hsa_circ_TMEM59
Synonym: circ_0012634
Host Gene: hsa-miR-147b
 
 
 
Disease basic information
DO ID:
 3498
DO name: pancreatic ductal adenocarcinoma
Disease details: pancreatic ductal adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human PDAC cell lines (PANC-1, BxPC-3, MIA PaCa-2, Capan-2), pancreatic ductal epithelial cell line (HPDE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: HIPK2
Associated microRNA: hsa-miR-147b
Biological function: Exosomal hsa_circ_0012634 inhibited PDAC cell growth and glycolysis in vitro, as well as tumorigenesis in vivo
Molecular mechanism: circ_0012634/hsa-miR-147b/HIPK2 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Exosomal hsa_circ_0012634 restrained PDAC progression via the miR-147b/HIPK2 pathway, confirming that hsa_circ_0012634 might serve as a diagnosis and treatment biomarker for PDAC.
Other information
Title:

Exosome-transmitted hsa_circ_0012634 suppresses pancreatic ductal adenocarcinoma progression through regulating miR-147b/HIPK2 axis.

Journal: Cancer Biol Ther
Published: 2023/6/16
PubMed ID: 37326330