circRNA basic information
circBase ID: hsa_circ_0064019
Name: hsa_circ_RABL2B
Synonym: circRABL2B
Host Gene: -
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Side population (SP) cells of A549 or PC9
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: YBX1, MUC5AC
Associated microRNA: -
Biological function: Overexpressed circRABL2B significantly inhibited cell malignant phenotypes, while it knock-down exerted opposite effects
Molecular mechanism: CircRABL2B/YBX1/MUC5AC axis, beta4/pSrc/p53 signaling
Survival: -
Supported No.:
 1
Description:

In conclusion, our data suggest that circRABL2B counteracts lung cancer progression via MUC5AC/integrin beta4/pSrc/p53 axis, which provides a rationale to enhance the efficacy of anti-MUCs treatment in lung cancer.
Other information
Title:

EIF4a3-regulated circRABL2B regulates cell stemness and drug sensitivity of lung cancer via YBX1-dependent downregulation of MUC5AC expression.

Journal: Int J Biol Sci
Published: 2023/6/16
PubMed ID: 37324942