circRNA basic information
circBase ID: -
Name: ssc_circ_PAPPA2
Synonym: sus_circPAPPA2
Host Gene: ssc-miR-2366
 
 
 
Disease basic information
DO ID:
9452
DO name: fatty liver disease
Disease details: fat
Species: others
Species details: pig
Sample type: PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: GK
Associated microRNA: ssc-miR-2366
Biological function: The overexpression of sus_circPAPPA2 significantly inhibited the differentiation of preadipocytes. The expression of sus_circPAPPA2 was increased after adding 100 nM of testosterone, and preadipocyte differentiation was significantly inhibited.
Molecular mechanism: Testosterone can affect preadipocyte differentiation by upregulating the expression of sus_circPAPPA2, sponging miR-2366 and regulating the expression of genes, such as GK.
Survival: -
Supported No.:
1
Description:

This study provides basic data enhancing the understanding of the interaction between the hormone environment and mir-2366/GK to regulate trait performance in pigs.

Other information
Title:

Sus_circPAPPA2 Regulates Fat Deposition in Castrated Pigs through the miR-2366/GK Pathway.

Journal: Biomolecules
Published: 2022/6/25
PubMed ID: 35740877