circRNA basic information
circBase ID: hsa_circ_0091579
Name: hsa_circ_GPC3
Synonym: circ_0091579
Host Gene: hsa-miR-1270
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human hepatoma cell lines (Hep3B, Huh7), human normal liver cell line (THLE-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: YAP1
Associated microRNA: hsa-miR-1270
Biological function: Inhibited circ_0091579 expression significantly suppressed proliferation and promoted apoptosis of HCC cells. Moreover, circ_0091579 knockdown inhibited tumor growth in vivo
Molecular mechanism: circ_0091579/hsa-miR-1270/YAP1 axis, miRNA sponge
Survival: -
Supported No.:
 6
Description:

Circ_0091579 promoted HCC progression by regulating the miR-1270/YAP1 axis, and our study might offer novel biomarkers and therapeutic targets for HCC.
Other information
Title:

Circ_0091579 Knockdown Inhibited HCC Proliferation and Glutamine Metabolism Through miR-1270/YAP1 Axis.

Journal: Biochem Genet
Published: 2023/6/14
PubMed ID: 37314551