circRNA basic information
circBase ID: hsa_circ_0080220
Name: hsa_circ_EGFR
Synonym: circEGFR
Host Gene: hsa-miR-1299
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: A human normal breast epithelial cell line (MCF-10A), human non-TNBC (NTNBC) cell lines (MCF-7, BT-474, SKBR-3), human TNBC cell lines (HCC-1806, MDA-MB-231, MDA-MB-486)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: EGFR
Associated microRNA: hsa-miR-1299
Biological function: In vitro studies confirmed that overexpression of circEGFR promoted the proliferation, migration, invasion, and EMT of TNBC cells and decreased the sensitivity of THP treatment while silencing circEGFR showed the opposite effect
Molecular mechanism: circEGFR/hsa-miR-1299/EGFR axis, miRNA sponge
Survival: poor
Supported No.:
 1
Description:

These results revealed circEGFR is a promising biomarker for TNBC diagnosis, therapeutic and prognosis.
Other information
Title:

CircEGFR reduces the sensitivity of pirarubicin and regulates the malignant progression of triple-negative breast cancer via the miR-1299/EGFR axis.

Journal: Int J Biol Macromol
Published: 2023/6/12
PubMed ID: 37302631