circRNA basic information
circBase ID: hsa_circ_0098181
Name: hsa_circ_SOX5
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Huh-7, HepG2, SK-Hep-1
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: QKI5, eEF2
Associated microRNA: -
Biological function: Ectopic expression of hsa_circ_0098181 delayed HCC metastasis in vitro and in vivo
Molecular mechanism: QKI5/hsa_circ_0098181/eEF2 axis, Hippo signaling pathway
Survival: -
Supported No.:
 3
Description:

Our study reveals changes in circRNA expression from chronic hepatitis, primary HCC, to metastatic HCC. Further, the QKI5-hsa_circ_0098181-eEF2-Hippo signaling pathway exerts a regulatory role in HCC.
Other information
Title:

Circular RNA hsa_circ_0098181 inhibits metastasis in hepatocellular carcinoma by activating the Hippo signaling pathway via interaction with eEF2.

Journal: Ann Hepatol
Published: 2023/6/8
PubMed ID: 37286166