circRNA basic information
circBase ID: hsa_circ_0001187
Name: hsa_circ_DOPEY2
Synonym: circ_0001187
Host Gene: hsa-miR-499a-5p
 
 
 
Disease basic information
DO ID:
 9119
DO name: acute myeloid leukemia
Disease details: acute myeloid leukemia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: AML cell lines (THP-1, Molm-13), 293 T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: RNF113A, METTL3
Associated microRNA: hsa-miR-499a-5p
Biological function: Knockdown of Circ_0001187 significantly promoted proliferation and inhibited apoptosis of AML cells in vitro and in vivo, whereas overexpression of Circ _0001187 exerted the opposite effects
Molecular mechanism: circ_0001187/hsa-miR-499a-5p/RNF113A/METTL3 axis, miRNA sponge
Survival: -
Supported No.:
 3
Description:

Collectively, our findings highlight the potential clinical implications of Circ _0001187 as a key tumor suppressor in AML via the miR-499a-5p/RNF113A/METTL3 pathway.
Other information
Title:

EIF4A3-induced Circ_0001187 facilitates AML suppression through promoting ubiquitin-proteasomal degradation of METTL3 and decreasing m6A modification level mediated by miR-499a-5p/RNF113A pathway.

Journal: Biomark Res
Published: 2023/6/7
PubMed ID: 37280654