circRNA basic information
circBase ID: hsa_circ_0010235
Name: hsa_circ_ALDH4A1
Synonym: circ_0010235
Host Gene: hsa-miR-379-5p
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human bronchial epithelial (HBE) cells, lung cancer cells (A549, H1299)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: E2F7
Associated microRNA: hsa-miR-379-5p
Biological function: Knockdown of circ_0010235 elevated DDP sensitivity, constrained proliferation, invasion and migration as well as fostered apoptosis in DDP-resistant lung cancer cells. Moreover, circ_0010235 silencing boosted DDP sensitivity and impeded tumor growth in lung cancer in vivo.
Molecular mechanism: circ_001023/hsa-miR-379-5p/E2F7 axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

Circ_0010235 knockdown reduced DDP resistance and tumor growth via miR-379-5p/ E2F7 axis in lung cancer, suggesting an effective therapeutic target for lung cancer patients.
Other information
Title:

Circ_0010235 confers cisplatin resistance in lung cancer by upregulating E2F7 through absorbing miR-379-5p.

Journal: Thorac Cancer
Published: 2023/6/6
PubMed ID: 37277864