circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: -
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human bladder epithelial cells (SV-HUC-1 cells), T24, EJ bladder cancer cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: VCP, Beclin 1
Associated microRNA: -
Biological function: CircHIPK3 downregulation promoted bladder cancer cell proliferation, while circHIPK3 overexpression inhibited proliferation. CircHIPK3 overexpression significantly suppressed autophagy in bladder cancer cells
Molecular mechanism: -
Survival: -
Supported No.:
 4
Description:

Thus, circHIPK3 may play an important role in bladder cancer by inhibiting VCP-mediated autophagy.
Other information
Title:

CircHIPK3 negatively regulates autophagy by blocking VCP binding to the Beclin 1 complex in bladder cancer.

Journal: Discov Oncol
Published: 2023/6/3
PubMed ID: 37269429