circRNA basic information
circBase ID: hsa_circ_0081241
Name: hsa_circ_TRRAP
Synonym: circTRRAP
Host Gene: hsa-miR-761
 
 
 
Disease basic information
DO ID:
 1287
DO name: cardiovascular system disease
Disease details: cardiomyocyte injury
Species: human
Species details: human
Sample type: cell line
Sample type details: human AC16 cardiomyocytes
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MAP3K2
Associated microRNA: hsa-miR-761
Biological function: Silencing circTRRAP attenuated hypoxia-evoked inflammation, apoptosis, and oxidative stress in human AC16 cardiomyocytes.
Molecular mechanism: CircTRRAP targeted miR-761, and miR-761 directly targeted and suppressed MAP3K2. CircTRRAP involved the post-transcriptional regulation of MAP3K2 through miR-761, indicating its competing endogenous RNA (ceRNA) activity.
Survival: -
Supported No.:
 1
Description:

circTRRAP can protect AC16 cardiomyocytes from hypoxia-evoked injury through the miR-761/MAP3K2 axis.
Other information
Title:

Regulation of a Novel CircTRRAP/miR-761/MAP3K2 CeRNA Cascade in Inflammation, Apoptosis, and Oxidative Stress in Human AC16 Cardiomyocytes under Hypoxia Conditions.

Journal: Int Heart J
Published: 2023/6/1
PubMed ID: 37258120