circRNA basic information
circBase ID: -
Name: hsa_circ_EML4
Synonym: circEML4
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ALKBH5, SOCS2
Associated microRNA: -
Biological function: Down-regulation of circEML4 in EVs from CSE-induced M2 macrophages reversed EVs-enhanced tumorigenicity and metastasis in NSCLC cells
Molecular mechanism: circEML4/ALKBH5/SOCS2 axis
Survival: -
Supported No.:
 1
Description:

This study also reveals that circEML4 in EVs from TAMs acts as a diagnostic biomarker for NSCLC, especially for patients with smoking history.
Other information
Title:

Smoking-Induced M2-TAMs, via circEML4 in EVs, Promote the Progression of NSCLC through ALKBH5-Regulated m6A Modification of SOCS2 in NSCLC Cells.

Journal: Adv Sci (Weinh)
Published: 2023/5/29
PubMed ID: 37246269