circRNA basic information
circBase ID: hsa_circ_0088214
Name: hsa_circ_PAPPA
Synonym: circ_0088214
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human osteosarcoma cells (MG63, U2OS )
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Over-expression of has_circ_0088214 significantly reduced osteosarcoma cells invasion, migration and resistance to cisplatin, but the apoptotic ratio was increased
Molecular mechanism: Akt signaling pathway
Survival: -
Supported No.:
 5
Description:

Up-regulation of hsa_circ_0088214 suppresses invasion, migration, cisplatin resistance but promoting apoptosis induced by H2O2 by inhibiting Akt signaling pathway in osteosarcoma.
Other information
Title:

Over-expression of hsa_circ_0088214 suppresses tumor progression by inhibiting Akt signaling pathway in osteosarcoma.

Journal: J Orthop Surg Res
Published: 2023/5/27
PubMed ID: 37237370