circRNA basic information
circBase ID: hsa_circ_0000670
Name: hsa_circ_C16orf72
Synonym: circ0000670
Host Gene: -
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human gastric cancer cell lines (HGC-27, AGS) , human gastric epithelial cells (GES-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: circ0000670 knockdown inhibited the promoting effects of cigarette smoke-induced exosomes on the stemness and EMT characteristic of GES-1 cells, whereas its overexpression had the opposite effect
Molecular mechanism: Wnt/beta-catenin pathway
Survival: -
Supported No.:
 2
Description:

Our findings indicated that exosomal circ0000670 promotes cigarette smoke-induced gastric cancer development, which might provide a new basis for the treatment of cigarette smoke-related gastric cancer.
Other information
Title:

Cigarette Smoke-Induced Gastric Cancer Cell Exosomes Affected the Fate of Surrounding Normal Cells via the Circ0000670/Wnt/beta-Catenin Axis.

Journal: Toxics
Published: 2023/5/26
PubMed ID: 37235279