circRNA basic information
circBase ID: hsa_circ_0111738
Name: hsa_circ_SOX13
Synonym: circ_0111738
Host Gene: hsa-miR-1233-3p
 
 
 
Disease basic information
DO ID:
 9538
DO name: multiple myeloma
Disease details: myeloma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: HIF-1
Associated microRNA: hsa-miR-1233-3p
Biological function: Overexpression of circ_0111738 reduced MM cell proliferation, migration, invasion, and angiogenesis while circ_0111738 led to opposite results. The anti-tumorigenic effect of circ_0111738 overexpression was also observed in vivo
Molecular mechanism: circ_0111738/hsa-miR-1233-3p/HIF-1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Our data suggest that circ_0111738 functioned as a competing endogenous RNA (ceRNA) and suppressed the oncogenic function of miR-1233-3p in MM by inactivating the HIF-1 pathway.

Other information
Title:

Hsa_circ_0111738 Inhibits Tumor Progression and Angiogenesis in Multiple Myeloma by Sponging miR-1233-3p to Regulate HIF-1 Signaling Pathway.

Journal: Arch Med Res
Published: 2023/5/22
PubMed ID: 37211508