circRNA basic information
circBase ID: hsa_circ_0087378
Name: hsa_circ_NTRK2
Synonym: circ_0087378
Host Gene: hsa-miR-199a-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human normal bronchial epithelial cell line (16HBE), human NSCLC cell lines (A549, NCI-H1299, NCI-H1975, HCC827, PC9)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: DDR1
Associated microRNA: hsa-miR-199a-5p
Biological function: The loss of circ_0087378 repressed the proliferation, colony formation, migration, invasion, but enhanced the apoptosis in NSCLC cells in vitro
Molecular mechanism: circ_0087378/hsa-miR-199a-5p/DDR1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Circ_0087378 promotes the malignant behavior of NSCLC cells_n vitro_y facilitating DDR1 via sponging miR-199a-5p. It may be a promising target for treatment.
Other information
Title:

Circ_0087378 intensifies the malignant behavior of non-small cell lung cancer cells in vitro by facilitating DDR1 via sponging miR-199a-5p.

Journal: Transl Lung Cancer Res
Published: 2023/5/18
PubMed ID: 37197635