circRNA basic information
circBase ID: hsa_circ_0063526
Name: hsa_circ_RANGAP1
Synonym: circRANGAP1
Host Gene: hsa-miR-653-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: NSCLC cell lines (H23, A549, H1975), normal human lung epithelial cell line BEAS-2B
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: COL11A1
Associated microRNA: hsa-miR-653-5p
Biological function: circRANGAP1 absence might hinder NSCLC cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in vitro. In vivo experiments illustrated that circRANGAP1 knockdown repressed tumor growth
Molecular mechanism: circRANGAP1/hsa-miR-653-5p/COL11A1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

CircRANGAP1 silencing might suppress NSCLC cell malignant biological behaviors, at least in part, through the miR-653-5p/COL11A1 axis.
Other information
Title:

Circular circRANGAP1 Contributes to Non-small Cell Lung Cancer Progression by Increasing COL11A1 Expression Through Sponging miR-653-5p.

Journal: Biochem Genet
Published: 2023/5/17
PubMed ID: 37193942