circRNA basic information
circBase ID: hsa_circ_0069094
Name: hsa_circ_S100P
Synonym: circ_0069094
Host Gene: hsa-miR-136-5p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Breast cancer cells (MCF-7, MDA-MB-468), normal breast epithelial cells (MCF-10A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: YWHAZ
Associated microRNA: hsa-miR-136-5p
Biological function: Circ_0069094 was overexpressed in paclitaxel (PTX)-resistant breast cancer tissues and cells, and the silencing of circ_0069094 decreased tumor growth, cell proliferation and cell invasion while increasing PTX sensitivity and cell apoptosis in PTX-resistant cells
Molecular mechanism: circ_0069094/hsa-miR-136-5p/YWHAZ axis, miRNA sponge
Survival: -
Supported No.:
 4
Description:

Circ_0069094 silencing improved PTX sensitivity in breast cancer progression through competitively sponging miR-136-5p.
Other information
Title:

Circ_0069094 regulates malignant phenotype and paclitaxel resistance in breast cancer cells via targeting the miR-136-5p/YWHAZ axis.

Journal: Thorac Cancer
Published: 2023/5/17
PubMed ID: 37192740