circRNA basic information
circBase ID: hsa_circ_0005615
Name: hsa_circ_NFATC3
Synonym: circ_0005615
Host Gene: hsa-miR-331-3p
 
 
 
Disease basic information
DO ID:
 9538
DO name: multiple myeloma
Disease details: myeloma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: MM cell lines (U266, MM1.S, NCI-H929), human normal plasma cells (nPCs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IGF1R
Associated microRNA: hsa-miR-331-3p
Biological function: Circ_0005615 inhibition retarded the proliferation and cell cycle progression, while reinforced the apoptosis of MM cells
Molecular mechanism: circ_0005615/hsa-miR-331-3p/IGF1R axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

Circ_0005615 downregulation blocked MM development by targeting miR-331-3p/IGF1R axis.
Other information
Title:

Circ_0005615 restrains the progression of multiple myeloma through modulating miR-331-3p and IGF1R regulatory cascade.

Journal: J Orthop Surg Res
Published: 2023/5/13
PubMed ID: 37173768